Metformin improves ovarian insulin signaling alterations caused by fetal programming
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چکیده
منابع مشابه
Metformin improves vascular function in insulin-resistant rats.
This study assessed the effect of metformin treatment on insulin, mean arterial pressure (MAP), and endothelial function in insulin-resistant (IR) rats. In addition, we assessed the direct effect of metformin in vitro. Sprague-Dawley rats were randomized to control (n=28) or IR (n=28) groups. Rats were further randomized to receive metformin (300 mg/kg) or placebo for 2 weeks. MAP and insulin w...
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Contents 1. Introduction 2. Gene expression for uterine proteins and nutrient transporters 2.1. Temporal and spatial changes in steroid hormone receptors in the uterus during the peri-implantation period of pregnancy 3. Pregnancy recognition 3.1. Luteotrophic versus antiluteolytic signaling for pregnancy recognition 3.2. Corpus luteum formation and regression 3.3. Pregnancy recognition signals ...
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OBJECTIVES The aim of this work was to study the effects of substrate deficiency and supplementation on cardiac function during fetal tachycardia. BACKGROUND Although sustained fetal tachycardia may lead to cardiac failure and intrauterine death, neonatal tachycardia is generally better tolerated. Fetal myocardial energy production relies almost solely on glucose as substrate. We hypothesized...
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Recent clinical studies found that fructose intake leads to insulin resistance and hypertension. Fructose consumption promotes protein fructosylation and formation of superoxide. In a previous study, we revealed that inhibition of superoxide production in the nucleus tractus solitarii (NTS) reduces blood pressure. Caffeine displays significant antioxidant ability in protecting membranes against...
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Type 2 diabetes (T2D) can go undiagnosed for years, leading to a stage where chronic high blood sugar produces complications such as delayed wound healing. Reports have shown that BLT2 activation improves keratinocyte migration and wound healing, as well as protecting the epidermal barrier through the promotion of actin polymerization. The goal of this study was to elucidate the role of BLT2 ex...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2019
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-18-0520